Chronic lack of sleep can negatively affect our immune cells, increasing some health risks: New study

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Losing an hour and a half of sleep each night on a consistent basis can lead to inflammatory disorders and cardiovascular disease, according to a new study from the Icahn School of Medicine at Mount Sinai in New York City.

The study – published in the Journal of Experimental Medicine on Wd., September 21, 2022 – found that a chronic lack of sleep Can affect a person’s immune cells and contribute to inflammation in the body.

“The increase in inflammation makes you susceptible to a whole bunch of problems, in particular cardiovascular diseases,” co-principal investigator Cameron McAlpine, assistant professor of medicine (cardiology) at Icahn Mount Sinai, told Fox News Digital. an interview.

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McAlpine is one of the researchers who participated in the new study.

Lead author Philip Swirsky, PhD, director of the Cardiovascular Research Institute at Icahn Mount Sinai, said in a news release, “This work emphasizes the importance of getting adults to sleep seven to eight consecutive hours to help prevent inflammation and disease, especially especially for people with underlying medical conditions.”

According to the lead author of a new study, adults should sleep seven to eight hours a night.

Adults should get seven to eight hours of sleep a night, “to help prevent inflammation and disease, especially for those with underlying medical conditions,” said lead author of a new study.
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Researchers said the study begins to identify the mechanisms in the body that link sleep and immunological health over the long term.

Studies have shown that in humans and mice, disturbed sleep can affect the rate of cell programming and production of immune cells; This can then cause immune cells to lose their effectiveness in protecting against disease.

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It can also affect the rate at which these cells are produced and potentially make the infection worse.

Another important observation [is that] that sleep reduces inflammation and, conversely, sleep disruption increases inflammation.”

The researchers also found disturbing evidence in a mouse model study that these effects may be long-lasting.

“This is important because it is yet another important observation that sleep reduces inflammation and, conversely, sleep disruption increases inflammation,” Swirsky said in a news release.

McAlpine told Fox News Digital that the aim of the study was to better understand how chronic sleep disruption can affect heart condition that develop over time due to inflammation.

A new study looked at the long-term effects of chronic sleep deprivation - compared to short-term interruptions of sleep over a few days.

A new study looked at the long-term effects of chronic sleep deprivation – compared to short-term interruptions of sleep over a few days.
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These findings, he said, could help with research involving other inflammatory diseases and conditions in the body, like gout.

The study looked at the long-term effects of chronic sleep deprivation, McAlpine said, compared to a short-term interruption in sleep over a few days.

He said the study helped identify biological mechanisms and pathways that link sleep and immune system health over the long term.

The group of participants decreased their sleep time by 90 minutes each night for six weeks – and had their blood drawn and re-analyzed.

The investigators looked at 14 healthy adults who regularly slept eight hours a night.

The participants were first monitored as they slept at least eight hours a night for six weeks. The team of researchers took blood samples and analyzed the participants’ immune cells.

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The group of participants decreased their sleep time by 90 minutes each night for six weeks – and had their blood drawn and re-analyzed.

In a new study all 14 participants

All 14 participants in a new study had “significant changes” in their immune cells, which were attributed to sleep deprivation, according to the findings.
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The investigators compared blood samples and found that all 14 participants had significant changes in their immune cells, which they attributed to lack of sleep.

blood samples with less sleep showed an altered DNA structure and increase the number of immune cells.

Typically, in an increased state of inflammation, there is an increased number of immune cells, health experts explained to Fox News Digital.

McAlpine also told Fox News Digital that the inflammatory state in rats with fragmented sleep did not change even after recovery from sleep.

The researchers also looked at the effects of sleep disturbances in the rats.

In the rats model, groups of rats were allowed to sleep non-stop, while another group was kept awake overnight for 16 weeks.

Reportedly, the rats in the disrupted sleep group went through recovery of uninterrupted sleep for 10 weeks.

“Our findings suggest that sleep recovery is not able to completely reverse the effects of poor quality sleep. We can detect the molecular imprint of insufficient sleep in immune stem cells even after weeks of sleep recovery.”
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The research team analyzed immune stem cells and cells from groups of mice — and the findings were consistent with human studies, McAlpine said.

“We found [both] Human and mice models [that] If you disturb sleep, you get increased swelling in the blood.”

McAlpine also told Fox News Digital that the inflammatory state in rats with fragmented sleep did not change even after recovery from sleep.

He noted that not all stem cells responded in the same way to insufficient sleep.

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“Unfortunately, in the human study, we did not assess recovery – but [we] observed recovery in rats. And in mice, we found that some parameters of inflammation returned to regular levels with sleep recovery – however, not all.”

McAlpine said some of the cells remained (after recovery from sleep) that drove the mice to inflammation.

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In a news release, the co-investigator said, “Our findings suggest that sleep recovery is not able to completely reverse the effects of poor quality sleep. We can detect the molecular imprint of insufficient sleep in immune stem cells.” Even after weeks of recovery sleep. This … can cause cells to react inappropriately, leading to inflammation and disease.”

McAlpine told Fox News Digital that the research team is planning more studies to understand which genes are being affected by sleep — or the pathways of genes that may respond to sleep. This will allow researchers to understand the effects of sleep in more detail.

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